Active Studies

The following studies are active. Use the links in the box on the left for information on each of the active studies being conducted by the PASA Consortium. 


AS140026-A5 Lori Davis, M.D. and Ismene Petrakis, M.D.

Study Type: Phase II Randomized Controlled Trial (RCT)
Protocol: Kappa Opioid Receptor Antagonism for the Treatment of Alcohol Use Disorder and Comorbid PTSD
Participating Site: Tuscaloosa Research & Education Advancement Corporation (TREAC)/Tuscaloosa VA Medical Center (TVAMC) (Satellite site at Birmingham VA), Connecticut Research & Education Foundation (CREEF) / VA Connecticut Healthcare System (VACT), and Wayne State University, Ann Arbor VA, Detroit VA


AS170014-A6 Christopher Verrico, Ph.D.

Study Type: Phase II Clinical Trial
Protocol: Lofexidine Combined with Buprenorphine for Reducing Symptoms of Post-Traumatic Stress Disorder and Opioid Use Relapse in Veterans
Participating Site: Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC)


AS140026-A3c Christopher Verrico, Ph.D. and Dewleen Baker, M.D.

Study Type: Phase I Pharmacokinetic Study
Protocol: Effects of Ethanol (EtOH) on the Pharmacokinetics of PT-150 (Formerly ORG34517)
Participating Site: Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC)


AS170014-A5 Marisa Roberto, Ph.D.

Study Type: Preclinical Study
Protocol: Preclinical testing of FKBP5 Inhibitors for alcohol use disorder-PTSD comorbidity
Participating Site: The Scripps Research Institute (TSRI)


AS170014-A7 Ismene Petrakis, M.D. 

Study Type: Phase phase 1, double-blind, placebo-controlled, within subjects
Protocol: Effect of Sublingual formulation of Dexmedetomidine HCl (BXCL501) on Ethanol in Heavy Drinkers with PTSD – Alcohol Interaction Study
Participating Site: VA Connecticut Healthcare System


AS170014-A9 B. Todd Webb, Ph.D.

Study Type: In Silico Study
Protocol: Leveraging multi-omic data integration for in silico compound prioritization
Participating Site: RTI GenOmics, Bioinformatics, and Translational Research Center (GOBOT)


AS170041-A8-Haile3 Colin Haile, M.D., Ph.D.

Study Type: Preclinical Study
Protocol: Development of a fentanyl vaccine to treat opioid use disorder
Participating Site: University of Houston